tricosanoyl sphingomyelin (d18:1/23:0)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of tricosanoyl sphingomyelin (d18:1/23:0)*
Metabolite Accession: GCST90200034
Name: tricosanoyl sphingomyelin (d18:1/23:0)*
Hmdb Id: HMDB0012105
Super Pathway: NA
Sub Pathway: NA
Inchikey: SXZWBNWTCVLZJN

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs174535

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.213
Position:
61551356
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-12.188
Reference Allele:
T
-log10(P):
-77.008
MAF:
0.344
Beta (Num):
-0.050
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.163
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.353
Position:
45412079
SE (Ratio):
0.030
Effect Allele:
T
Z-score (Ratio):
-11.755
Reference Allele:
C
-log10(P):
-71.782
MAF:
0.084
Beta (Num):
-0.135
Novel Locus:
No
SE (Num):
0.026
Beta (Den):
0.218
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism.11[1], 12[2]

Ratio Explanation:

This ratio reflects the balance between sphingolipid and ether phospholipid classes, modulated by APOE-mediated lipoprotein transport, a key factor in overall lipid homeostasis.13[1], 14[2], 15[3], 16[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

APOE variants influence lipoprotein metabolism, causing dyslipidemia (e.g., pure hypercholesterolemia), which is reflected in the altered ratio of lipid species and contributes to the risk of cardiovascular diseases such as myocardial infarction and coronary atherosclerosis.5[1], 17[2], 18[3], 19[4]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data