1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to sphingomyelin (d18:1/20:0, d16:1/22:0)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Metabolite Accession: GCST90200044
Name: 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Hmdb Id: HMDB0011375
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVYPOHCSLJZFED

Denominator Metabolite

Structure of sphingomyelin (d18:1/20:0, d16:1/22:0)*
Metabolite Accession: GCST90200001
Name: sphingomyelin (d18:1/20:0, d16:1/22:0)*
Hmdb Id: HMDB0012102
Super Pathway: NA
Sub Pathway: NA
Inchikey: AADLTHQNYQJHQV

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.392
Position:
45412079
SE (Ratio):
0.037
Effect Allele:
T
Z-score (Ratio):
10.552
Reference Allele:
C
-log10(P):
-58.259
MAF:
0.084
Beta (Num):
0.200
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
-0.192
SE (Den):
0.027
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen biosynthesis.9[1], 10[2], 11[3], 12[4]

Denominator Metabolite Explanation:

Sphingolipid metabolism, Ceramide biosynthesis.13[1], 14[2], 15[3], 16[4], 17[5]

Ratio Explanation:

The ratio reflects lipoprotein lipid composition; APOE variants alter the packaging of plasmalogens and sphingomyelins, influencing their circulatory balance.18[1], 19[2], 20[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

APOE variants alter lipid transport, modifying lipoprotein composition, which is reflected by the plasmalogen/sphingomyelin ratio.5[1], 18[2], 19[3] This genetically-driven dyslipidemia is a known causal factor for hypercholesterolemia, atherosclerosis, and myocardial infarction.21[4], 22[5], 23[6], 24[7], 25[8]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data