tricosanoyl sphingomyelin (d18:1/23:0)* to 1-oleoylglycerol (18:1)

Numerator Metabolite

Structure of tricosanoyl sphingomyelin (d18:1/23:0)*
Metabolite Accession: GCST90200034
Name: tricosanoyl sphingomyelin (d18:1/23:0)*
Hmdb Id: HMDB0012105
Super Pathway: NA
Sub Pathway: NA
Inchikey: SXZWBNWTCVLZJN

Denominator Metabolite

Structure of 1-oleoylglycerol (18:1)
Metabolite Accession: GCST90199676
Name: 1-oleoylglycerol (18:1)
Hmdb Id: HMDB0011567
Super Pathway: NA
Sub Pathway: NA
Inchikey: RZRNAYUHWVFMIP

Associated Genomic Regions

Region: rs72654473

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.262
Position:
45414399
SE (Ratio):
0.033
Effect Allele:
A
Z-score (Ratio):
-7.987
Reference Allele:
C
-log10(P):
-34.215
MAF:
0.107
Beta (Num):
-0.126
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.136
SE (Den):
0.025
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE APOC1 TOMM40 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerolipid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio may reflect the balance between sphingolipid and glycerolipid metabolism, which is influenced by ApoE's role in overall lipid transport and homeostasis.11[1], 12[2], 13[3], 4[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in APOE are strongly associated with altered lipid profiles, increasing the risk for dyslipidemia and cardiovascular diseases like myocardial infarction and hypertension.1[1], 14[2], 2[3], 15[4]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data