tricosanoyl sphingomyelin (d18:1/23:0)* to 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)

Numerator Metabolite

Structure of tricosanoyl sphingomyelin (d18:1/23:0)*
Metabolite Accession: GCST90200034
Name: tricosanoyl sphingomyelin (d18:1/23:0)*
Hmdb Id: HMDB0012105
Super Pathway: NA
Sub Pathway: NA
Inchikey: SXZWBNWTCVLZJN

Denominator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Associated Genomic Regions

Region: rs445925

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.256
Position:
45415640
SE (Ratio):
0.032
Effect Allele:
A
Z-score (Ratio):
-7.925
Reference Allele:
G
-log10(P):
-33.716
MAF:
0.107
Beta (Num):
-0.126
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.130
SE (Den):
0.025
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOC1 APOE TOMM40 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio of a sphingomyelin to a glycerophosphoethanolamine likely reflects alterations in lipoprotein composition and lipid transport, which are regulated by APOE.11[1], 12[2], 13[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

APOE variants are strongly linked to dyslipidemia and atherosclerosis.14[1], 15[2], 16[3] The ratio likely reflects APOE-driven changes in lipoprotein lipid content, a key factor in the development of coronary artery disease, myocardial infarction, and other observed cardiovascular phenotypes.11[4], 17[5]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data