lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Structure of lignoceroyl sphingomyelin (d18:1/24:0)
Metabolite Accession: GCST90200020
Name: lignoceroyl sphingomyelin (d18:1/24:0)
Hmdb Id: HMDB0011697
Super Pathway: NA
Sub Pathway: NA
Inchikey: QEDPUVGSSDPBMD

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.283
Position:
45412079
SE (Ratio):
0.035
Effect Allele:
T
Z-score (Ratio):
-8.125
Reference Allele:
C
-log10(P):
-35.339
MAF:
0.084
Beta (Num):
-0.156
Novel Locus:
Yes ✔️
SE (Num):
0.027
Beta (Den):
0.127
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingomyelin metabolism, ceramide synthesis.8[1], 9[2], 10[3], 11[4]

Denominator Metabolite Explanation:

Ether lipid (plasmalogen) metabolism.12[1], 13[2], 14[3], 15[4]

Ratio Explanation:

The ratio likely reflects altered lipid metabolism driven by APOE, where dysfunctional lipid transport affects the balance between sphingomyelin and ether phospholipid pools.16[1], 17[2], 18[3], 19[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

APOE variants influence circulating lipid profiles, predisposing individuals to hypercholesterolemia and an increased risk of cardiovascular diseases like myocardial infarction and atherosclerosis, which are observed in the associated phenotypes.4[1], 20[2], 21[3], 22[4], 23[5]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data