cholesterol to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of cholesterol
Metabolite Accession: GCST90200368
Name: cholesterol
Hmdb Id: HMDB0000067
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVYWMOMLDIMFJA

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.303
Position:
45412079
SE (Ratio):
0.031
Effect Allele:
T
Z-score (Ratio):
-9.790
Reference Allele:
C
-log10(P):
-50.441
MAF:
0.084
Beta (Num):
-0.085
Novel Locus:
No
SE (Num):
0.027
Beta (Den):
0.218
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Cholesterol metabolism, Steroid biosynthesis.10[1], 11[2], 12[3], 13[4], 14[5]

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen biosynthesis.15[1], 16[2], 17[3], 18[4], 19[5]

Ratio Explanation:

This ratio contrasts cholesterol levels with a specific plasmalogen, likely reflecting the balance between sterol regulation and polyunsaturated fatty acid-containing ether lipid metabolism.20[1], 21[2], 22[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in APOE and FADS genes alter lipoprotein and fatty acid metabolism, affecting cholesterol levels and plasmalogen composition.7[1], 1[2], 23[3] This dysregulation of distinct lipid classes contributes to the increased risk of dyslipidemia, cholelithiasis, and atherosclerotic cardiovascular disease observed in the associated phenotypes.24[4], 21[5], 25[6], 26[7], 27[8]

Phenotype Driver:

Gene-centric:[APOE]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data