1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* to sphingomyelin (d18:1/19:0, d19:1/18:0)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Denominator Metabolite

Metabolite Accession: GCST90200131
Name: sphingomyelin (d18:1/19:0, d19:1/18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.273
Position:
45412079
SE (Ratio):
0.034
Effect Allele:
T
Z-score (Ratio):
8.021
Reference Allele:
C
-log10(P):
-34.490
MAF:
0.084
Beta (Num):
0.152
Novel Locus:
Yes ✔️
SE (Num):
0.028
Beta (Den):
-0.121
SE (Den):
0.026
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, ether lipid metabolism.6[1]

Denominator Metabolite Explanation:

Sphingolipid metabolism, ceramide synthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio likely reflects altered lipoprotein particle composition or membrane lipid dynamics, modulated by APOE's role in transporting both lipid classes.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

APOE variants dysregulate lipoprotein metabolism, reflected in this lipid ratio, which contributes to the development of associated phenotypes like hypercholesterolemia, myocardial infarction, and atherosclerosis.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:[APOE]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data