1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1) to palmitoyl sphingomyelin (d18:1/16:0)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Metabolite Accession: GCST90200044
Name: 1-(1-enyl-stearoyl)-2-oleoyl-gpe (p-18:0/18:1)
Hmdb Id: HMDB0011375
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVYPOHCSLJZFED

Denominator Metabolite

Structure of palmitoyl sphingomyelin (d18:1/16:0)
Metabolite Accession: GCST90199876
Name: palmitoyl sphingomyelin (d18:1/16:0)
Hmdb Id: HMDB0010169
Super Pathway: NA
Sub Pathway: NA
Inchikey: RWKUXQNLWDTSLO

Associated Genomic Regions

Region: rs141622900

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.382
Position:
45426792
SE (Ratio):
0.040
Effect Allele:
A
Z-score (Ratio):
9.511
Reference Allele:
G
-log10(P):
-47.723
MAF:
0.058
Beta (Num):
0.241
Novel Locus:
No
SE (Num):
0.033
Beta (Den):
-0.141
SE (Den):
0.032
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOC1 APOE APOC4 APOC4-APOC2 TOMM40

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis5[1], 6[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism7[1], 8[2]

Ratio Explanation:

The ratio reflects the balance between plasmalogen and sphingomyelin pathways. APOE and APOC1 influence this balance by regulating lipoprotein metabolism, which transports components for both pathways.1[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the APOE/APOC1 cluster alter lipoprotein metabolism, influencing the availability of precursors for both plasmalogen and sphingomyelin synthesis. This altered lipid balance is associated with an increased risk of myocardial infarction and other cardiovascular diseases.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:APOE/APOC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data