1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)* to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Denominator Metabolite

Metabolite Accession: GCST90200047
Name: sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.342
Position:
45412079
SE (Ratio):
0.035
Effect Allele:
T
Z-score (Ratio):
9.902
Reference Allele:
C
-log10(P):
-51.551
MAF:
0.084
Beta (Num):
0.218
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
-0.124
SE (Den):
0.027
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid and glycerophospholipid metabolism.10[1], 11[2], 12[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism.13[1], 14[2], 15[3]

Ratio Explanation:

A decreased ratio of plasmalogen to sphingomyelin may reflect altered lipid metabolism influenced by APOE, potentially impacting membrane structure and signaling.16[1], 17[2], 18[3], 19[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in APOE, a key lipid transport protein, alters the balance between plasmalogens and sphingolipids.16[1], 17[2], 20[3] This imbalance is associated with hypercholesterolemia, myocardial infarction, and other cardiovascular phenotypes, likely due to APOE's central role in lipoprotein metabolism and clearance.7[4], 21[5], 22[6]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data