lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*

Numerator Metabolite

Structure of lignoceroyl sphingomyelin (d18:1/24:0)
Metabolite Accession: GCST90200020
Name: lignoceroyl sphingomyelin (d18:1/24:0)
Hmdb Id: HMDB0011697
Super Pathway: NA
Sub Pathway: NA
Inchikey: QEDPUVGSSDPBMD

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Metabolite Accession: GCST90200061
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Hmdb Id: HMDB0011342
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZVVYJAAMWXATNY

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.280
Position:
45412079
SE (Ratio):
0.034
Effect Allele:
T
Z-score (Ratio):
-8.348
Reference Allele:
C
-log10(P):
-37.206
MAF:
0.084
Beta (Num):
-0.156
Novel Locus:
Yes ✔️
SE (Num):
0.027
Beta (Den):
0.124
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

1[1], 5[2], 6[3], 7[4] Sphingolipid biosynthesis, ceramide synthesis.

Denominator Metabolite Explanation:

8[1] Plasmalogen biosynthesis, ether lipid metabolism.

Ratio Explanation:

9[1], 10[2], 11[3], 12[4] The ratio of lignoceroyl sphingomyelin to a plasmalogen likely reflects altered lipid transport and metabolism influenced by APOE's function in lipoprotein dynamics.

Ratio Evidence:

13[1], 14[2], 15[3], 16[4] metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered APOE function modifies lipoprotein composition and lipid transport, affecting both sphingomyelin and plasmalogen levels. T13[1], 14[2], 17[3], 16[4]his dysregulation is linked to an increased risk of hypercholesterolemia, cardiovascular diseases like myocardial infarction, and metabolic disorders, which are prominent in the associated phenotypes.

Phenotype Driver:

1[1], 7[2] Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data