palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0) to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Metabolite Accession: GCST90200237
Name: palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.316
Position:
45412079
SE (Ratio):
0.031
Effect Allele:
T
Z-score (Ratio):
-10.314
Reference Allele:
C
-log10(P):
-55.757
MAF:
0.084
Beta (Num):
-0.098
Novel Locus:
No
SE (Num):
0.028
Beta (Den):
0.218
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Plasmalogen synthesis.12[1], 13[2], 14[3]

Ratio Explanation:

The ratio of a sphingolipid to a plasmalogen may reflect APOE-driven changes in lipoprotein composition and membrane dynamics, as APOE transports both lipid classes.15[1], 16[2], 17[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in APOE, a primary lipid transport protein, are strongly associated with dyslipidemia and cardiovascular diseases like myocardial infarction.1[1], 18[2], 19[3], 20[4] The ratio of a sphingolipid to a plasmalogen likely reflects these APOE-mediated alterations in lipoprotein metabolism, linking genetic variation to phenotype.15[5], 21[6], 17[7], 22[8]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data