lignoceroyl sphingomyelin (d18:1/24:0) to 1-(1-enyl-stearoyl)-gpe (p-18:0)*

Numerator Metabolite

Structure of lignoceroyl sphingomyelin (d18:1/24:0)
Metabolite Accession: GCST90200020
Name: lignoceroyl sphingomyelin (d18:1/24:0)
Hmdb Id: HMDB0011697
Super Pathway: NA
Sub Pathway: NA
Inchikey: QEDPUVGSSDPBMD

Denominator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
-0.285
Position:
45412079
SE (Ratio):
0.033
Effect Allele:
T
Z-score (Ratio):
-8.589
Reference Allele:
C
-log10(P):
-39.272
MAF:
0.084
Beta (Num):
-0.156
Novel Locus:
Yes ✔️
SE (Num):
0.027
Beta (Den):
0.129
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Phosphatidylethanolamine Biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects altered lipid metabolism, potentially linking sphingolipid pathways influenced by APOE with plasmalogen levels, both implicated in cardiovascular health.9[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The APOE e4 variant is associated with increased LDL cholesterol and risk of myocardial infarction; this altered lipid environment likely influences the levels of both lignoceroyl sphingomyelin and 1-(1-enyl-stearoyl)-gpe, contributing to the observed cardiovascular and metabolic phenotypes.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data