palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Structure of palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Metabolite Accession: GCST90200035
Name: palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Hmdb Id: HMDB0010168
Super Pathway: NA
Sub Pathway: NA
Inchikey: QHZIGNLCLJPLCU

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.269
Position:
45412079
SE (Ratio):
0.034
Effect Allele:
T
Z-score (Ratio):
-7.960
Reference Allele:
C
-log10(P):
-33.998
MAF:
0.084
Beta (Num):
-0.142
Novel Locus:
Yes ✔️
SE (Num):
0.027
Beta (Den):
0.127
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism, phospholipid biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Plasmalogen and glycerophospholipid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects altered lipid metabolism where APOE variants impact the transport and balance between sphingolipid and ether phospholipid classes, affecting membrane composition.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

APOE variants alter lipid transport, leading to dyslipidemia, which is strongly associated with cardiovascular phenotypes like hypercholesterolemia, atherosclerosis, and myocardial infarction.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data