palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*

Numerator Metabolite

Structure of palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Metabolite Accession: GCST90200035
Name: palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Hmdb Id: HMDB0010168
Super Pathway: NA
Sub Pathway: NA
Inchikey: QHZIGNLCLJPLCU

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Metabolite Accession: GCST90200061
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Hmdb Id: HMDB0011342
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZVVYJAAMWXATNY

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.266
Position:
45412079
SE (Ratio):
0.033
Effect Allele:
T
Z-score (Ratio):
-8.031
Reference Allele:
C
-log10(P):
-34.572
MAF:
0.084
Beta (Num):
-0.142
Novel Locus:
Yes ✔️
SE (Num):
0.027
Beta (Den):
0.124
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism.10[1], 7[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between sphingolipid and plasmalogen metabolism, both influenced by apolipoprotein-mediated lipid transport which is associated with cardiovascular phenotypes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered APOE and APOC1 function likely disrupts lipid transport, affecting the balance of membrane components like sphingolipids and plasmalogens, contributing to dyslipidemia and increasing the risk of cardiovascular diseases such as myocardial infarction and atherosclerosis.1[1], 2[2], 3[3], 12[4]

Phenotype Driver:

Gene-centric:APOE/APOC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data