palmitoyl dihydrosphingomyelin (d18:0/16:0)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Metabolite Accession: GCST90200035
Name: palmitoyl dihydrosphingomyelin (d18:0/16:0)*
Hmdb Id: HMDB0010168
Super Pathway: NA
Sub Pathway: NA
Inchikey: QHZIGNLCLJPLCU

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.261
Position:
45412079
SE (Ratio):
0.031
Effect Allele:
T
Z-score (Ratio):
-8.429
Reference Allele:
C
-log10(P):
-37.892
MAF:
0.084
Beta (Num):
-0.142
Novel Locus:
Yes ✔️
SE (Num):
0.027
Beta (Den):
0.120
SE (Den):
0.027
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

GPI anchor biosynthesis.9[1], 10[2], 11[3]

Ratio Explanation:

This ratio compares two membrane lipids. APOC1 may influence the lipid composition of lipoproteins, which can affect the lipid makeup of cell membranes systemically.12[1], 13[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in APOC1 are associated with altered plasma lipid levels and an increased risk for cardiovascular disease, which is reflected in the numerous cardiometabolic phenotypes like cholelithiasis and ischaemic heart disease.14[1], 15[2], 16[3], 17[4]

Phenotype Driver:

Gene-centric:APOC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data