tricosanoyl sphingomyelin (d18:1/23:0)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of tricosanoyl sphingomyelin (d18:1/23:0)*
Metabolite Accession: GCST90200034
Name: tricosanoyl sphingomyelin (d18:1/23:0)*
Hmdb Id: HMDB0012105
Super Pathway: NA
Sub Pathway: NA
Inchikey: SXZWBNWTCVLZJN

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs483082

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.190
Position:
45416178
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-8.997
Reference Allele:
G
-log10(P):
-42.905
MAF:
0.224
Beta (Num):
-0.075
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.115
SE (Den):
0.018
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOC1 APOE TOMM40 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between two major lipid classes transported by lipoproteins; APOE's function and isoform can influence this lipid composition balance.10[1], 11[2], 12[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered APOE-mediated lipid transport likely dysregulates hepatic lipid balance, reflected by this ratio. This contributes to lipotoxicity and inflammation, promoting progression to cirrhosis and hepatocellular carcinoma, which are associated phenotypes.13[1], 14[2], 15[3], 16[4]

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data