behenoyl sphingomyelin (d18:1/22:0)* to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of behenoyl sphingomyelin (d18:1/22:0)*
Metabolite Accession: GCST90199997
Name: behenoyl sphingomyelin (d18:1/22:0)*
Hmdb Id: HMDB0012103
Super Pathway: NA
Sub Pathway: NA
Inchikey: FJJANLYCZUNFSE

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs7412

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.322
Position:
45412079
SE (Ratio):
0.032
Effect Allele:
T
Z-score (Ratio):
-9.996
Reference Allele:
C
-log10(P):
-52.498
MAF:
0.084
Beta (Num):
-0.104
Novel Locus:
No
SE (Num):
0.027
Beta (Den):
0.218
SE (Den):
0.028
No CNV overlap
rQTL cluster:
8
Reaction Distance:
NA
Closest Genes:
APOE TOMM40 APOC1 PVRL2 APOC4

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.11[1]

Ratio Explanation:

The ratio of behenoyl sphingomyelin to a plasmalogen may reflect altered lipid membrane composition and signaling, influenced by APOE's role in lipid transport.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in APOE and APOC1 alters lipoprotein metabolism, affecting the levels of specific sphingomyelins and plasmalogens, which is associated with an increased risk of hypercholesterolemia, atherosclerosis, and myocardial infarction.

Phenotype Driver:

Gene-centric:APOE

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data