1-stearoyl-2-oleoyl-gpc (18:0/18:1) to 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpc (18:0/18:1)
Metabolite Accession: GCST90200028
Name: 1-stearoyl-2-oleoyl-gpc (18:0/18:1)
Hmdb Id: HMDB0008038
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATHVAWFAEPLPPQ

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Associated Genomic Regions

Region: rs28456

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.197
Position:
61589481
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
12.904
Reference Allele:
A
-log10(P):
-86.051
MAF:
0.309
Beta (Num):
0.036
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.161
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs4683440

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.113
Position:
142669479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-7.909
Reference Allele:
G
-log10(P):
-33.586
MAF:
0.474
Beta (Num):
-0.056
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.056
SE (Den):
0.015
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, GPI anchor biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance between common phospholipid synthesis and the specific production of arachidonic acid-containing GPI-anchored lipids, influenced by FADS enzyme activity.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the fatty acid pool, decreasing arachidonic acid needed for the denominator and impacting lipid profiles, which is linked to hypercholesterolemia and cholelithiasis.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data