1-stearoyl-2-linoleoyl-gpe (18:0/18:2)* to 1-stearoyl-2-oleoyl-gpe (18:0/18:1)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Denominator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Associated Genomic Regions

Region: rs174547

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.185
Position:
61570783
SE (Ratio):
0.008
Effect Allele:
C
Z-score (Ratio):
22.642
Reference Allele:
T
-log10(P):
-259.667
MAF:
0.339
Beta (Num):
0.283
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.098
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs9653945

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Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.108
Position:
142660706
SE (Ratio):
0.008
Effect Allele:
A
Z-score (Ratio):
-13.337
Reference Allele:
G
-log10(P):
-91.762
MAF:
0.354
Beta (Num):
0.003
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.111
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.5[1]

Ratio Explanation:

This ratio reflects the balance of glycerophosphoethanolamines containing linoleic acid (18:2) versus oleic acid (18:1), influenced by FADS desaturase activity on fatty acid pools.1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter the balance of omega-6 and omega-9 fatty acids, impacting lipid metabolism and inflammation.7[1], 8[2] This dysregulation is linked to metabolic phenotypes like Type 2 diabetes, hypercholesterolemia, and cholelithiasis, which are associated with the FADS locus.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data