1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)* to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs4683709

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.166
Position:
142653249
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-8.070
Reference Allele:
G
-log10(P):
-34.892
MAF:
0.336
Beta (Num):
-0.077
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.089
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis, Phospholipid Metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid signaling.5[1], 6[2]

Ratio Explanation:

The ratio reflects the activity of FADS1/FADS2 enzymes, which are involved in converting oleic acid (18:1) precursors to arachidonic acid (20:4).1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants are associated with altered polyunsaturated fatty acid levels and are linked to hypercholesterolemia and cholelithiasis.8[1], 9[2], 10[3] Altered FADS activity influences the balance of pro-inflammatory and anti-inflammatory lipids, potentially driving the pathogenesis of these metabolic diseases.11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data