1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.255
Position:
61588305
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
18.195
Reference Allele:
A
-log10(P):
-168.661
MAF:
0.344
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.149
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs8736

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.252
Position:
54677189
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
18.361
Reference Allele:
C
-log10(P):
-171.707
MAF:
0.435
Beta (Num):
0.179
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.073
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

Region: rs9653945

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
0.203
Position:
142660706
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
14.662
Reference Allele:
G
-log10(P):
-110.407
MAF:
0.355
Beta (Num):
0.137
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.066
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

GPI biosynthesis

Denominator Metabolite Explanation:

GPI biosynthesis

Ratio Explanation:

The ratio reflects MBOAT7 and FADS1/2 activity. Lower MBOAT7 or higher FADS1/2 activity favors the numerator by decreasing arachidonoyl-GPI formation or increasing oleoyl-GPI precursors.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Gene-centric:MBOAT7

Phenotype Driver:

Reduced MBOAT7 expression, linked to genetic variants, alters phosphatidylinositol composition, which can impact inflammatory pathways and lipid metabolism, contributing to phenotypes like cholelithiasis and inflammatory bowel disease.1[1], 2[2], 5[3], 6[4], 7[5]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data