pregnenetriol disulfate* to 16a-hydroxy dhea 3-sulfate

Numerator Metabolite

Metabolite Accession: GCST90200238
Name: pregnenetriol disulfate*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Associated Genomic Regions

Region: rs72818671

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.213
Position:
96775001
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-9.747
Reference Allele:
G
-log10(P):
-50.018
MAF:
0.117
Beta (Num):
-0.052
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.162
SE (Den):
0.023
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 CYP2C19 C10orf129 PDLIM1

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.033
Position:
99075038
SE (Ratio):
0.037
Effect Allele:
C
Z-score (Ratio):
-27.575
Reference Allele:
T
-log10(P):
-383.721
MAF:
0.035
Beta (Num):
0.012
Novel Locus:
No
SE (Num):
0.039
Beta (Den):
1.044
SE (Den):
0.039
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis and metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis and metabolism.9[1], 10[2]

Ratio Explanation:

This ratio reflects the relative activities of different branches of steroid hormone metabolism, potentially influenced by CYP2C8 enzymatic activity on steroid precursors.3[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered CYP2C8 activity can shift steroid hormone profiles and influence inflammatory pathways through its metabolism of arachidonic acid, plausibly affecting BMI and inflammation (CRP).11[1], 12[2], 13[3]

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data