metabolonic lactone sulfate to 5alpha-androstan-3beta,17beta-diol disulfate

Numerator Metabolite

Metabolite Accession: GCST90200257
Name: metabolonic lactone sulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs80159642

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.219
Position:
96719846
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
10.722
Reference Allele:
A
-log10(P):
-60.085
MAF:
0.194
Beta (Num):
0.174
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.045
SE (Den):
0.017
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C9 CYP2C8 CYP2C19 CYP2C18 C10orf129

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism

Denominator Metabolite Explanation:

Androgen metabolism

Ratio Explanation:

Ratio of two inactivated androgens suggests altered flux in steroid metabolism, potentially modulated by CYP3A enzymes acting on upstream androgen precursors.5[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic factors like CYP3A4 influence androgen metabolism, reflected in the steroid ratio.1[1], 3[2], 6[3] Androgens are known regulators of hematopoiesis, and altered steroid profiles may plausibly affect platelet production and count.7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:CYP3A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data