1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Metabolite Accession: GCST90200039
Name: 1-stearoyl-2-linoleoyl-gpe (18:0/18:2)*
Hmdb Id: HMDB0008994
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDTWOEYVDRKKCR

Associated Genomic Regions

Region: rs12638256

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.113
Position:
142655290
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-10.383
Reference Allele:
G
-log10(P):
-56.478
MAF:
0.469
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.005
SE (Den):
0.015
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoethanolamine biosynthesis.10[1], 11[2]

Denominator Metabolite Explanation:

Glycerophosphoethanolamine biosynthesis.10[1], 12[2]

Ratio Explanation:

The ratio reflects the balance between two different species of glycerophosphoethanolamines, differing in their fatty acid composition, within the same general pathway.10[1], 12[2], 11[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

ATR's role in promoting cholesterol synthesis may influence overall lipid metabolism.6[1], 7[2], 13[3], 8[4], 9[5] Altered lipid profiles, including this specific ratio, are associated with disorders of lipoprotein metabolism and elevated ALT, a marker of liver stress which can be linked to dyslipidemia.13[6], 14[7], 15[8], 16[9]

Phenotype Driver:

Gene-centric:ATR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data