1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.256
Position:
61588305
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
14.958
Reference Allele:
A
-log10(P):
-114.807
MAF:
0.343
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.149
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs4683709

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Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
0.187
Position:
142653249
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
11.027
Reference Allele:
G
-log10(P):
-63.437
MAF:
0.336
Beta (Num):
0.110
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.4[1], 5[2]

Ratio Explanation:

This ratio reflects FADS1 activity; lower FADS1 function decreases arachidonic acid (20:4) synthesis, thus increasing the ratio of its precursor phospholipids to product phospholipids.1[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity alters the balance of pro- and anti-inflammatory lipids, which is linked to inflammatory conditions like IBD and asthma, and to lipid disorders like hypercholesterolemia and cholelithiasis, all of which are associated phenotypes.6[1], 7[2], 8[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data