1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Metabolite Accession: GCST90200063
Name: 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Hmdb Id: HMDB0008946
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPWUZHVZZKSTPV

Associated Genomic Regions

Region: rs12638256

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Clumped rQTL variant

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SNP Summary

Chr:
3
Beta (Ratio):
-0.133
Position:
142655290
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-9.519
Reference Allele:
G
-log10(P):
-47.799
MAF:
0.469
Beta (Num):
-0.118
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.014
SE (Den):
0.015
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

Region: rs8523

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.125
Position:
10981053
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
8.956
Reference Allele:
G
-log10(P):
-42.536
MAF:
0.430
Beta (Num):
0.050
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.075
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 GCM2 SMIM13

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylethanolamine Biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects the conversion efficiency of oleic acid to downstream long-chain fatty acids like DHA, a process influenced by ELOVL2 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ELOVL2 function can impair the synthesis of DHA (denominator), altering lipid profiles.7[1], 8[2] This dyslipidemia is linked to disorders of lipoprotein metabolism and may contribute to elevated Alanine aminotransferase (ALT) levels.9[3], 10[4]

Phenotype Driver:

Gene-centric:ELOVL2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data