1-palmitoyl-2-oleoyl-gpe (16:0/18:1) to 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Metabolite Accession: GCST90200331
Name: 1-palmitoyl-2-oleoyl-gpe (16:0/18:1)
Hmdb Id: HMDB0005320
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHQVHHIBKUMWTI

Denominator Metabolite

Structure of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Metabolite Accession: GCST90200079
Name: 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Hmdb Id: HMDB0009069
Super Pathway: NA
Sub Pathway: NA
Inchikey: PECSWFQRRFRZPW

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.225
Position:
61593005
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
16.379
Reference Allele:
A
-log10(P):
-137.165
MAF:
0.346
Beta (Num):
0.103
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.122
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs200698395;rs6440123

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
3
Beta (Ratio):
0.135
Position:
142659361
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
9.938
Reference Allele:
A
-log10(P):
-51.917
MAF:
0.353
Beta (Num):
0.118
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
132
Reaction Distance:
NA
Closest Genes:
PAQR9 U2SURP PCOLCE2 TRPC1 CHST2

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism and fatty acid desaturation.6[1], 3[2]

Ratio Explanation:

This ratio reflects FADS enzyme activity, comparing a glycerophosphoethanolamine with a polyunsaturated fatty acid (20:4) in the denominator to one without.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters enzyme activity, changing the balance of glycerophospholipids.9[1], 7[2], 10[3] This dysregulation of fatty acid metabolism contributes to phenotypes like cholelithiasis, dyslipidemia, and type 2 diabetes through effects on inflammation and cellular lipid handling.10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data