androstenediol (3beta,17beta) disulfate (1) to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (1)
Metabolite Accession: GCST90199842
Name: androstenediol (3beta,17beta) disulfate (1)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs56390141

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.270
Position:
96851277
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-10.142
Reference Allele:
A
-log10(P):
-53.981
MAF:
0.115
Beta (Num):
-0.099
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.171
SE (Den):
0.025
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 PDLIM1 SORBS1

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.144
Position:
99075038
SE (Ratio):
0.045
Effect Allele:
C
Z-score (Ratio):
-25.208
Reference Allele:
T
-log10(P):
-321.170
MAF:
0.034
Beta (Num):
-0.316
Novel Locus:
No
SE (Num):
0.038
Beta (Den):
0.829
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.678
Position:
100197642
SE (Ratio):
0.068
Effect Allele:
A
Z-score (Ratio):
-9.971
Reference Allele:
G
-log10(P):
-52.247
MAF:
0.016
Beta (Num):
-0.279
Novel Locus:
No
SE (Num):
0.056
Beta (Den):
0.399
SE (Den):
0.063
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.9[1], 10[2]

Ratio Explanation:

This ratio may reflect the balance between the production of a disulfated and a monosulfated androstenediol metabolite, potentially influenced by CYP2C8-mediated hydroxylation activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced *CYP2C8* function may alter steroid metabolism, contributing to changes in inflammatory markers like C-reactive protein and white blood cell count, and potentially influencing metabolic phenotypes such as BMI and uric acid levels.5[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data