androstenediol (3alpha, 17alpha) monosulfate (3) to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs112152869

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
10
Beta (Ratio):
-0.380
Position:
96784589
SE (Ratio):
0.031
Effect Allele:
C
Z-score (Ratio):
-12.225
Reference Allele:
A
-log10(P):
-77.457
MAF:
0.118
Beta (Num):
-0.214
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.166
SE (Den):
0.024
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 CYP2C19 PDLIM1

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
7
Beta (Ratio):
-1.669
Position:
99075038
SE (Ratio):
0.053
Effect Allele:
C
Z-score (Ratio):
-31.196
Reference Allele:
T
-log10(P):
-490.249
MAF:
0.033
Beta (Num):
-0.840
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
0.829
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
7
Beta (Ratio):
-0.783
Position:
100197642
SE (Ratio):
0.081
Effect Allele:
A
Z-score (Ratio):
-9.695
Reference Allele:
G
-log10(P):
-49.503
MAF:
0.015
Beta (Num):
-0.383
Novel Locus:
No
SE (Num):
0.055
Beta (Den):
0.399
SE (Den):
0.063
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen steroid metabolism.8[1], 9[2]

Ratio Explanation:

This ratio may reflect altered CYP2C8-mediated steroid metabolism, influencing the balance of different androgenic compounds.3[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered CYP2C8 activity can shift androgen metabolism, impacting BMI and inflammation (CRP), as androgens are linked to both body composition and inflammatory processes.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data