16a-hydroxy dhea 3-sulfate to DHEAS

Numerator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs112152869

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.247
Position:
96784589
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
10.668
Reference Allele:
A
-log10(P):
-59.507
MAF:
0.119
Beta (Num):
0.162
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
-0.085
SE (Den):
0.021
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 CYP2C19 PDLIM1

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.468
Position:
99075038
SE (Ratio):
0.040
Effect Allele:
C
Z-score (Ratio):
36.896
Reference Allele:
T
-log10(P):
-684.498
MAF:
0.034
Beta (Num):
1.044
Novel Locus:
No
SE (Num):
0.039
Beta (Den):
-0.423
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.738
Position:
100197642
SE (Ratio):
0.060
Effect Allele:
A
Z-score (Ratio):
12.302
Reference Allele:
G
-log10(P):
-78.417
MAF:
0.015
Beta (Num):
0.491
Novel Locus:
No
SE (Num):
0.059
Beta (Den):
-0.247
SE (Den):
0.054
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism

Ratio Explanation:

The ratio reflects the 16-alpha hydroxylation of DHEAS, a reaction catalyzed by CYP2C8, indicating its enzymatic activity on this steroid substrate.5[1]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Altered CYP2C8 activity, reflected by the metabolite ratio, may influence inflammatory pathways (CRP, WBC) and metabolic parameters (BMI, Uric Acid) through its broad substrate metabolism.6[1], 7[2], 8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data