androstenediol (3beta,17beta) monosulfate (2) to andro steroid monosulfate c19h28o6s (1)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs11598823

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.281
Position:
96848749
SE (Ratio):
0.028
Effect Allele:
T
Z-score (Ratio):
-10.116
Reference Allele:
A
-log10(P):
-53.717
MAF:
0.116
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.171
SE (Den):
0.025
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 PDLIM1 SORBS1

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.176
Position:
99075038
SE (Ratio):
0.047
Effect Allele:
C
Z-score (Ratio):
-24.851
Reference Allele:
T
-log10(P):
-312.231
MAF:
0.034
Beta (Num):
-0.347
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
0.829
SE (Den):
0.041
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.669
Position:
100197642
SE (Ratio):
0.071
Effect Allele:
A
Z-score (Ratio):
-9.477
Reference Allele:
G
-log10(P):
-47.388
MAF:
0.016
Beta (Num):
-0.270
Novel Locus:
No
SE (Num):
0.060
Beta (Den):
0.399
SE (Den):
0.063
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.6[1]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.7[1]

Ratio Explanation:

This ratio likely reflects the balance of androgen metabolism, which can be altered by CYP2C8 activity on either the steroid metabolites or their precursors.3[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP2C8 variant may alter androgen balance, influencing BMI and inflammatory markers like CRP and WBC.9[1], 10[2], 11[3] CYP2C8's role in metabolizing inflammatory mediators could also contribute to these phenotypes.12[4]

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data