androstenediol (3beta,17beta) monosulfate (2) to 16a-hydroxy dhea 3-sulfate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Associated Genomic Regions

Region: rs56390141

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.274
Position:
96851277
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-10.313
Reference Allele:
A
-log10(P):
-55.751
MAF:
0.116
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.165
SE (Den):
0.023
No CNV overlap
rQTL cluster:
70
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 PDLIM1 SORBS1

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.391
Position:
99075038
SE (Ratio):
0.045
Effect Allele:
C
Z-score (Ratio):
-30.809
Reference Allele:
T
-log10(P):
-478.257
MAF:
0.034
Beta (Num):
-0.347
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
1.044
SE (Den):
0.039
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34048349

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.761
Position:
100197642
SE (Ratio):
0.068
Effect Allele:
A
Z-score (Ratio):
-11.251
Reference Allele:
G
-log10(P):
-65.941
MAF:
0.016
Beta (Num):
-0.270
Novel Locus:
No
SE (Num):
0.060
Beta (Den):
0.491
SE (Den):
0.059
No CNV overlap
rQTL cluster:
89
Reaction Distance:
NA
Closest Genes:
FBXO24 PCOLCE MOSPD3 LRCH4 TFR2

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Steroidogenesis, Androgen and estrogen metabolism.12[1], 13[2], 14[3], 15[4], 16[5]

Ratio Explanation:

This ratio may reflect the balance between different steroid hormone metabolic pathways, potentially influenced by *CYP2C8* activity on one or both sulfated steroid metabolites.4[1], 17[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered *CYP2C8* function likely modifies steroid metabolism, evidenced by the androstenediol monosulfate to 16a-hydroxy DHEA sulfate ratio, which may influence inflammatory and metabolic phenotypes like BMI, C-reactive protein, and white blood cell count through complex downstream effects of steroid hormone signaling.

Phenotype Driver:

Gene-centric:CYP2C8

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data